Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1
نویسندگان
چکیده
منابع مشابه
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is selectively and abundantly expressed in the brain, and its activity is required for normal synaptic function. Here, we show that UCH-L1 functions in maintaining normal synaptic structure in hippocampal neurons. We found that UCH-L1 activity is rapidly upregulated by NMDA receptor activation, which leads to an increa...
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Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by tremor, bradykinesia, postural instability and muscular rigidity. Neuropathologically, it is defined by cell loss in the substantia nigra associated with the presence of intraneuronal inclusions called Lewy bodies (LB) and processes engorged with proteinaceous material, the Lewy neurites. The recent identi...
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Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1, aka PGP9.5) is an abundant, neuronal deubiquitinating enzyme that has also been suggested to possess E3 ubiquitin-protein ligase activity and/or stabilize ubiquitin monomers in vivo. Recent evidence implicates dysregulation of UCH-L1 in the pathogenesis and progression of human cancers. Although typically only expressed in neurons, high levels o...
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Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain where, remarkably, it is estimated to make up 1-5% of total neuronal protein. Although it comprises only 223 amino acids it has one of the most complicated 3D knotted structures yet discovered. Beyond its expression in neurons UCH-L1 has only very limited expression in other healthy tissues but it is highly...
متن کاملElectronic Theses and Dissertations Uc San Diego Title: Structure/function Analysis of Ubiquitin C-terminal Hydrolase-l1 (uch-l1) Structure/function Analysis of Ubiquitin C-terminal Hydrolase – L1 (uch-l1)
Abstract: Parkinson's disease (PD) and Alzheimer's disease (AD), two of the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Mammalian neuronal cells abundantly express a deubiquitinating (DUB) enzyme, Ubiquitin Carboxy-terminal hydrolase L1 (UCH-L1), which is involved in the pathogenesis of both of these neurodegenerative diseases. This DUB is selec...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2009
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1817-09.2009